Virginia at Notre Dame odds and lines

Virginia Football Opens as Big Underdog at Notre Dame in Week 12
The Virginia Cavaliers opened as more than three-touchdown underdogs in their week 12 road game at the Notre Dame Fighting Irish this Saturday at 3:30pm (NBC).
First look: Virginia at Notre Dame odds and lines
Looking at Saturday’s Virginia at Notre Dame college football odds, lines and trends. Here’s what you need to know.
Virginia vs. Notre Dame Prediction: Cavaliers Will Need More Than Luck Fighting the Irish
Not only are the Notre Dame Fighting Irish 4-0 all-time against the Virginia Cavaliers, but they cruised to a 28-3 victory in their 2021 meeting. Entering Week 12 as over three-touchdown underdogs, do the Cavaliers have enough talent to at least cover the spread?
Virginia vs. Notre Dame prediction: Odds, expert picks, QB matchup, betting trends, and stats
Let’s talk about the spread, at least. Notre Dame is 6-2-1 against the spread this year. They have an average margin of victory of 27.2 and are +11.5 to the average spread. This Notre Dame team is special. Defensively, they are exceptional. They are in the top five in defensive success rate and EPA margin.
Notre Dame’s Star Defender Ruled OUT for Game Against Virginia
When Notre Dame hosts Virginia for senior day in South Bend on Saturday the Fighting Irish will be without one of their most important defenders. Graduate senior Howard Cross III will miss the game after spraining his ankle against Florida State.
Notre Dame is favored by more than three touchdowns against Virginia
According to FanDuel SportsBook, the Irish are 22.5 point favorites over Virginia with an over/under of 50.5. Currently, Notre Dame is ranked 12 in the country for points per game
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