Looking at Saturday’s Virginia at Notre Dame college football odds, lines and trends. Here’s what you need to know.

Not only are the Notre Dame Fighting Irish 4-0 all-time against the Virginia Cavaliers, but they cruised to a 28-3 victory in their 2021 meeting. Entering Week 12 as over three-touchdown underdogs, do the Cavaliers have enough talent to at least cover the spread?

Let’s talk about the spread, at least. Notre Dame is 6-2-1 against the spread this year. They have an average margin of victory of 27.2 and are +11.5 to the average spread. This Notre Dame team is special. Defensively, they are exceptional. They are in the top five in defensive success rate and EPA margin.

When Notre Dame hosts Virginia for senior day in South Bend on Saturday the Fighting Irish will be without one of their most important defenders. Graduate senior Howard Cross III will miss the game after spraining his ankle against Florida State.

According to FanDuel SportsBook, the Irish are 22.5 point favorites over Virginia with an over/under of 50.5. Currently, Notre Dame is ranked 12 in the country for points per game