CRB-913 brain levels are 15-fold lower than monlunabant in lean miceDose-response demonstrated for a range of 5 to 80 mg/kg/day achieving up to ...

Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...

The research study tested a murine equivalent of SRK-439 in a diet-induced obesity, or DIO, mouse model. All mice were given a high-fat diet, followed by either metformin or control for four weeks.

Preclinical study design The research study tested a murine equivalent of SRK-439 in a diet-induced obesity (DIO) mouse model. All mice were given a high-fat diet, followed by either metformin (50 ...

To investigate the response of reproductive tissues to hyperinsulinemia, we used a mouse model of infertility associated with DIO. Hence, it is likely that a hormonal milieu that differs between ...

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Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company developing first-in-class medicines based on ...

This study uncovers the hepatic vagal nerve's influence on circadian food intake, presenting new avenues for obesity treatment through targeted interventions.

Dose-response demonstrated for a range of 5 to 80 mg/kg/day achieving up to 38% weight loss in DIO mice Semaglutide treatment followed by its replacement with CRB-913 demonstrated continued weight ...

Scholar Rock (SRRK) announced new preclinical data that support the potential of SRK-439, a highly selective investigational antimyostatin ...

CRB-913 brain levels are 15-fold lower than monlunabant in lean mice Dose-response demonstrated for a range of 5 to 80 mg/kg/day achieving up to 38% weight loss in DIO mice Semaglutide treatment ...