There may not be two teams more injured than the Los Angeles Rams and San Francisco 49ers, which will have a big impact on Sunday’s game at SoFi Stadium. The 49ers are missing Christian McCaffrey, Deebo Samuel and possibly George Kittle, while the Rams will be without Cooper Kupp, Puka Nacua and two starting offensive linemen.

George Kittle, Deebo Samuel, and Christian McCaffrey have all scored multiple touchdowns in the 49ers’ recent visits to SoFi Stadium. None are expected in uniform for Sunday’s return. Kittle is doubtful,

George Kittle is doubtful for Sunday's game at Los Angeles with a hamstring injury, while two of San Francisco's top defenders, Nick Bosa and Charvarius Ward, are listed as questionable.