Hughes is a city in Yukon-Koyukuk Census Area, Alaska, United States. The population was 85 at the 2020 census, up from 77 in 2010. Acco…Hughes is a city in Yukon-Koyukuk Census Area, Alaska, United States. The population was 85 at the 2020 census, up from 77 in 2010. According to the United States Census Bureau, the city has a total area of 3.1 square miles, all of it land.